Article

Single-cell heterogeneity and dynamic evolution of Ph-like acute lymphoblastic leukemia patient with novel TPR-PDGFRB fusion gene

2022-12-15

Abstract excerpt

<h4>Background: </h4> Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a refractory and recurrent subtype of B-cell ALL enriched with kinase-activating rearrangements. Incomplete understanding of the heterogeneity within the tumor cells presents a major challenge for the diagnosis and therapy of Ph-like ALL. Methods Single-cell RNA sequencing (scRNA-seq) was performed on 10,273 bone marr...

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Literature Corpus work: 7b8d7d33-8761-5130-a33a-8b023ae4d46c
DOI: 10.21203/rs.3.rs-2372797/v1

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