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Targeting senescent stemlike subpopulations in Philadelphia chromosome–like acute lymphoblastic leukemia

7 Jan 2025

Abstract excerpt

ABSTRACT: Philadelphia chromosome-like B-cell acute lymphoblastic leukemia (Ph-like ALL) is driven by genetic alterations that induce constitutive kinase signaling and is associated with chemoresistance and high relapse risk in children and adults. Preclinical studies in the most common CRLF2-rearranged/JAK pathway-activated Ph-like ALL subtype have revealed variable responses to JAK inhibitor-based therapies,...

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PMID: 39774844
DOI: 10.1182/blood.2024026482

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