Article

Comparing ancestry calibration approaches for a trans-ancestry colorectal cancer polygenic risk score

2023-10-24

Abstract excerpt

<h4>Background</h4> Colorectal cancer (CRC) is a complex disease with monogenic, polygenic and environmental risk factors. Polygenic risk scores (PRS) are being developed to identify high polygenic risk individuals. Due to differences in genetic background, PRS distributions vary by ancestry, necessitating calibration. <h4>Methods</h4> We compared four calibration methods using the All of Us Research Program Whole...

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Literature Corpus work: 7b8197c7-f42b-5690-abb8-35da54f49fcf
DOI: 10.1101/2023.10.23.23296753

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