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Article

Comparing Ancestry Standardization Approaches for a Transancestry Colorectal Cancer Polygenic Risk Score.

Genetic epidemiology - 1 Jan 2025

Rosenthal Elisabeth A, Hsu Li, Thomas Minta, Peters Ulrike, Kachulis Christopher, Patterson Karynne, Jarvik Gail P

Abstract excerpt

Colorectal cancer (CRC) is a complex disease with monogenic, polygenic and environmental risk factors. Polygenic risk scores (PRSs) aim to identify high polygenic risk individuals. Due to differences in genetic background, PRS distributions vary by ancestry, necessitating standardization. We compared four post-hoc methods using the All of Us Research Program Whole Genome Sequence data for a transancestry CRC PRS....

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PMID: 39315597
DOI: 10.1002/gepi.22590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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