Article

Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking

2020-11-24

Abstract excerpt

<h4>ABSTRACT</h4> The SARS-CoV-2 macrodomain (Mac1) within the non-structural protein 3 (Nsp3) counteracts host-mediated antiviral ADP-ribosylation signalling. This enzyme is a promising antiviral target because catalytic mutations render viruses non-pathogenic. Here, we report a massive crystallographic screening and computational docking effort, identifying new chemical matter primarily targeting the active sit...

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Identifiers and source

Literature Corpus work: 621dd7dc-c0cf-5982-af4b-c8266994b9d1
DOI: 10.1101/2020.11.24.393405

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