The pain target NaV1.7 is expressed late during human iPS cell differentiation into sensory neurons as determined in high resolution imaging

Abstract excerpt

Human induced pluripotent stem cells (iPS cells) are efficiently differentiated into sensory neurons. These cells express the voltage-gated sodium channel Na V 1.7, which is a validated pain target. Na V 1.7 deficiency leads to pain insensitivity, whereas Na V 1.7 gain-of-function mutants are associated with chronic pain. Here we used CRISPR/Cas9 genome editing to generate a HA-tag Na V 1.7 to follow its expressio...

Topics

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• Erythromelalgia
• Ganglia, Spinal
• Induced Pluripotent Stem Cells
• Models, Animal
• Mutation
• NAV1.7 Voltage-Gated Sodium Channel
• Pain
• Sensory Receptor Cells

Identifiers and source

Literature Corpus work

7b44669b-4d0d-583d-bf7c-3e02712ead0e

DOI

10.21203/rs.3.rs-3716212/v1