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Article

Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population.

Molecular & cellular proteomics : MCP - 1 Sept 2018

Williams Evan G, Wu Yibo, Wolski Witold, Kim Jun Yong, Lan Jiayi, Hasan Moaraj, Halter Christian, Jha Pooja, Ryu Dongryeol, Auwerx Johan, Aebersold Ruedi

Abstract excerpt

We have used SWATH mass spectrometry to quantify 3648 proteins across 76 proteomes collected from genetically diverse BXD mouse strains in two fractions (mitochondria and total cell) from five tissues: liver, quadriceps, heart, brain, and brown adipose (BAT). Across tissues, expression covariation between genes' proteins and transcripts-measured in the same individuals-broadly aligned. Covariation was however far...

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Genetic Variation
Mass Spectrometry
Mice
Mitochondria
Mitochondrial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29945935
DOI: 10.1074/mcp.RA118.000554
PMCID: PMC6126393

Genes

ABCC6
IMPDH2
MTAP
SOAT2

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