Article

Beyond Structural Bioinformatics for Genomics with Dynamics Characterization of an Expanded KRAS Mutational Landscape

2023-04-28

Abstract excerpt

<h4> ABSTRACT </h4> Current capabilities in genomic sequencing outpace functional interpretations. Our previous work showed that 3D protein structure calculations enhance mechanistic understanding of genetic variation in sequenced tumors and patients with rare diseases. The KRAS GTPase is among the critical genetic factors driving cancer and germline conditions. Because KRAS-altered tumors frequently harbor one...

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Literature Corpus work: 7b2d4cd0-1ce4-54a4-8a63-2ff498c08d4d
DOI: 10.1101/2023.04.28.536249

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