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Article

Mutations influence the conformational dynamics of the GDP/KRAS complex.

Journal of biomolecular structure & dynamics - 1 Nov 2025

Shen Congcong, Yin Jie, Wang Min, Yu Zhiping, Xu Xin, Zhou Zhongshun, Hu Yingshi, Xia Caijuan, Hu Guodong

Abstract excerpt

Mutations near allosteric sites can have a significant impact on the function of KRAS. Three specific mutations, K104Q, G12D/K104Q, and G12D/G75A, which are located near allosteric positions, were selected to investigate the molecular mechanisms behind mutation-induced influences on the activity of KRAS. Gaussian accelerated molecular dynamics (GaMD) simulations followed by the principal component analysis (PCA)...

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Share to Allosteric Regulation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38529923
DOI: 10.1080/07391102.2024.2331627

Genes

KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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