Article

A Knockout of the IFITM3 Gene Increases the Sensitivity of WI-38 VA13 Cells to the Influenza a Virus

2023-12-08

Abstract excerpt

One of the ways to regulate the sensitivity of human cells to the influenza virus is to knock out genes of the innate immune response. Promising targets for the knockout are genes of the interferon-inducible transmembrane protein (IFITM) family, in particular the IFITM3 gene, whose product limits the entry of a virus into the cell by blocking the fusion of the viral and endosomal membranes. In this study, by means...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7b2be06f-e5d5-5f83-8f5b-b7c2c28b9a2b
DOI: 10.20944/preprints202312.0628.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Knockout of the IFITM3 Gene Increases the Sensitivity of WI-38 VA13 Cells to the Influenza a VirusDOI 10.20944/preprints202312.0628.v1Read

Antiviral Protection by IFITM3 In VivoSemantic proximity Read

Influenza A Virus Facilitates Its Infectivity by Activating p53 to Inhibit the Expression of Interferon-Induced Transmembrane ProteinsSemantic proximity Read

Low basal expression and slow induction of IFITM3 puts immune cells at risk of influenza A infectionSemantic proximity Read

IFITM-Family Proteins: The Cell's First Line of Antiviral DefenseSemantic proximity Read

IFITM Genes, Variants, and Their Roles in the Control and Pathogenesis of Viral InfectionsSemantic proximity Read

Human IFITM3 restricts Chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteractionSemantic proximity Read

Human IFITM3 restricts chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteractionSemantic proximity Read

Ifitm3 limits the severity of acute influenza in mice.Semantic proximity Read

Opposing roles of endosomal innate immunity proteins IFITM3 and TLR7 in human metapneumovirus infectionSemantic proximity Read

Interferon-Induced Transmembrane Proteins Inhibit Infection by the Kaposi’s Sarcoma-Associated Herpesvirus and the Related Rhesus Monkey Rhadinovirus in a Cell Type-Specific MannerSemantic proximity Read

More than meets the I: the diverse antiviral and cellular functions of interferon-induced transmembrane proteinsSemantic proximity Read

Chicken Interferon-Inducible Transmembrane Protein 3 Restricts Influenza Viruses and Lyssaviruses In VitroSemantic proximity Read