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Article

Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19.

PLoS genetics - 1 Mar 2022

Palmos Alish B, Millischer Vincent, Menon David K, Nicholson Timothy R, Taams Leonie S, Michael Benedict, Sunderland Geraint, Griffiths Michael J, Hübel Christopher, Breen Gerome

Abstract excerpt

In November 2021, the COVID-19 pandemic death toll surpassed five million individuals. We applied Mendelian randomization including >3,000 blood proteins as exposures to identify potential biomarkers that may indicate risk for hospitalization or need for respiratory support or death due to COVID-19, respectively. After multiple testing correction, using genetic instruments and under the assumptions of Mendelian...

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Identifiers

PMID: 35239653
DOI: 10.1371/journal.pgen.1010042
PMCID: PMC8893330

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