Article

Multi-Ancestry Mendelian Randomization of Omics Traits Revealing Putative Drug Targets of COVID-19 Severity

2022-03-09

Abstract excerpt

Background: Recent omic studies prioritised several drug targets associated with coronavirus disease 2019 (COVID-19) severity. However, little evidence was provided to systematically estimate the effect of drug targets on COVID-19 severity in multiple ancestries.<br><br>Methods: In this study, we applied Mendelian randomization (MR) and colocalization approaches to understand the putative causal effects of 16,059...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 742849a5-764e-508f-ab2f-8c89d300b9bd
DOI: 10.2139/ssrn.4053476

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-Ancestry Mendelian Randomization of Omics Traits Revealing Putative Drug Targets of COVID-19 SeverityDOI 10.2139/ssrn.4053476Read

Multi-ancestry Mendelian randomization of omics traits revealing drug targets of COVID-19 severity.Semantic proximity Read

Multi-ancestry omic Mendelian randomization revealing putative drug targets of COVID-19 severitySemantic proximity Read

A year of Covid-19 GWAS results from the GRASP portal reveals potential SARS-CoV-2 modifiersSemantic proximity Read

Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19.Semantic proximity Read

Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19Semantic proximity Read

A Network Medicine Approach to Investigation and Population-based Validation of Disease Manifestations and Drug Repurposing for COVID-19Semantic proximity Read

Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseasesSemantic proximity Read

Exploiting shared omics architecture and causal association between complex traits and COVID-19Semantic proximity Read

Single-cell transcriptome-wide Mendelian randomization and colocalization reveals immune-mediated regulatory mechanisms and drug targets for COVID-19Semantic proximity Read

Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19.Semantic proximity Read

A year of COVID-19 GWAS results from the GRASP portal reveals potential genetic risk factorsSemantic proximity Read

A second update on mapping the human genetic architecture of COVID-19Semantic proximity Read