Article

Full-thickness spatial transcriptomics of the human uterus reveals basalis niche architecture and regeneration gradients during menstrual breakdown

2026-06-10

Abstract excerpt

The human endometrium (uterine lining) undergoes cyclical breakdown and scarless regeneration during each menstrual cycle, representing an exceptional model of adult tissue renewal. Regeneration is driven primarily by progenitor cells retained within the deep, basalis compartment during menstruation, yet the full-depth spatiotemporal dynamics of this process have remained understudied due to anatomical and technic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2a3220a1-69e5-579b-8c36-8bcdab63a96c
DOI: 10.64898/2026.06.08.730878

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Full-thickness spatial transcriptomics of the human uterus reveals basalis niche architecture and regeneration gradients during menstrual breakdownDOI 10.64898/2026.06.08.730878Read

An integrated single-cell reference atlas of the human endometriumSemantic proximity Read

An organoid model of the menstrual cycle reveals the role of the luminal epithelium in regeneration of the human endometriumSemantic proximity Read

Quantifying inflammatory resolution in human menstruation reveals disease-specific failure modes and enables a non-invasive diagnostic for endometriosisSemantic proximity Read

Endometrial Stem/Progenitor Cells–Their Role in Endometrial Repair and RegenerationSemantic proximity Read

Single cell RNAseq provides a molecular and cellular cartography of changes to the human endometrium through the menstrual cycleSemantic proximity Read

Cellular heterogeneity and dynamics of the human uterus in healthy premenopausal womenSemantic proximity Read

Induction of menstruation in mice reveals the regulation of menstrual sheddingSemantic proximity Read

Single-cell RNA sequencing and lineage tracing confirm mesenchyme to epithelial transformation (MET) contributes to repair of the endometrium at menstruationSemantic proximity Read

Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitroSemantic proximity Read

Single cell RNA sequencing and lineage tracing confirm mesenchyme to epithelial transformation (MET) contributes to repair of the endometrium at menstruationSemantic proximity Read

Single cell mapping of the human endometrium and first trimester decidua identifies distinct epithelial and stromal cell contributions to fertilitySemantic proximity Read