Article

Telomeric antisense oligonucleotides reduce premature aging phenotypes in telomerase mutant zebrafish

2025-05-27

Abstract excerpt

Telomerase activity is restricted in somatic cells, resulting in progressive telomere shortening. Telomere erosion eventually activates the DNA damage response (DDR), inducing cell-cycle arrest and cellular senescence or apoptosis. We previously reported that telomere dysfunction induces the transcription of telomeric non-coding RNAs (tncRNAs) which are critical mediators of DDR activation. Blocking tncRNAs with t...

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Literature Corpus work: 7acfbcc3-d93e-55ee-879d-f88508991663
DOI: 10.1101/2025.05.23.655694

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