Article

The age of heterozygous telomerase mutant parents influences the adult phenotype of their offspring irrespective of genotype in zebrafish

2018-02-22

Abstract excerpt

<h4>Background: </h4> Mutations in proteins involved in telomere maintenance lead to a range of human diseases, including dyskeratosis congenita, idiopathic pulmonary fibrosis and cancer. Telomerase functions to add telomeric repeats back onto the ends of chromosomes, however non-canonical roles of components of telomerase have recently been suggested. Methods: Here we use a zebrafish telomerase mutant which harbo...

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Literature Corpus work: 7a615f87-1dba-58dd-b132-f4147e0b8142
DOI: 10.12688/wellcomeopenres.12530.2

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