Back to search

Article

Lack of telomerase rescues cancer and shorter lifespan of zebrafish tp53 mutants

2023-09-11

Abstract excerpt

Telomerase activity is restricted in humans and telomere attrition occurs in several tissues accompanying natural aging. Critically short telomeres trigger DNA damage responses and activate p53 that result in apoptosis or replicative senescence. These processes reduce cell proliferation and disrupt tissue homeostasis, thus contributing to systemic aging. Zebrafish have restricted telomerase expression and telomere...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b931a047-4fd8-5d2f-ac10-b94ad3c27412
DOI
10.21203/rs.3.rs-3306400/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Lack of telomerase rescues cancer and shorter lifespan of zebrafish tp53 mutantsDOI 10.21203/rs.3.rs-3306400/v1
Telomerase Is Required for Zebrafish LifespanSemantic proximity
Gut-specific telomerase expression counteracts systemic aging in telomerase-deficient zebrafishSemantic proximity
Premature aging in telomerase-deficient zebrafish.Semantic proximity
Telomeres in aging and disease: lessons from zebrafishSemantic proximity
Telomere length is an epigenetic trait - Implications for the use of telomerase-deficient organisms to model human disease.Semantic proximity
TELOMERASE DEPLETION ACCELERATES AGEING OF THE ZEBRAFISH BRAINSemantic proximity
Telomere shortening produces an inflammatory environment that promotes tumor invasiveness in zebrafishSemantic proximity
Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish.Semantic proximity
Short Telomeres in Key Tissues Initiate Local and Systemic Aging in ZebrafishSemantic proximity
A Non-Canonical Function of Zebrafish Telomerase Reverse Transcriptase Is Required for Developmental HematopoiesisSemantic proximity
Expression of Telomerase and Telomere Length Are Unaffected by either Age or Limb Regeneration in Danio rerioSemantic proximity
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.Semantic proximity
Select a neighboring publication to make it the new centre.