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Premature aging in telomerase-deficient zebrafish.

Disease models & mechanisms - 1 Sept 2013

Anchelin Monique, Alcaraz-Pérez Francisca, Martínez Carlos M, Bernabé-García Manuel, Mulero Victoriano, Cayuela María L

Abstract excerpt

The study of telomere biology is crucial to the understanding of aging and cancer. In the pursuit of greater knowledge in the field of human telomere biology, the mouse has been used extensively as a model. However, there are fundamental differences between mouse and human cells. Therefore, additional models are required. In light of this, we have characterized telomerase-deficient zebrafish (Danio rerio) as the...

Topics

Aging, Premature
Animals
Apoptosis
Breeding
Chromosome Aberrations
Humans
Longevity
Male
Mice
Mutation
Telomerase
Telomere

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Telomere Shortening

Testis

Tumor Suppressor Protein p53

Zebrafish

Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23744274
DOI: 10.1242/dmm.011635
PMCID: PMC3759330

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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