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Focal amplification of <i>FAL1</i>, an oncogenic enhancer lncRNA mapping to chromosome 1q is associated with dysregulated BMI1/p21 axis and an adverse event in intracranial ependymomas

2021-03-26

Abstract excerpt

Gain of chromosome 1q locus is a common cytogenetic feature associated with intracranial ependymomas; however, candidate non-coding RNAs on this locus have not been identified. Recent studies have reported somatic copy number alterations for long non coding RNA (lncRNA) FAL1/FALEC residing on chromosome 1q to stabilize BMI1, an epigenetic repressor and PRC1 component, leading with to downregulation of p21/CDKN1A t...

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Literature Corpus work
7ac2617c-5c44-5c36-821b-f5369de696ed
DOI
10.1101/2021.03.24.21254063
Open publication

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Focal amplification of <i>FAL1</i>, an oncogenic enhancer lncRNA mapping to chromosome 1q is associated with dysregulated BMI1/p21 axis and an adverse event in intracranial ependymomasDOI 10.1101/2021.03.24.21254063
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