Article
A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer.
Cancer cell - 8 Sept 2014
Hu Xiaowen, Feng Yi, Zhang Dongmei, Zhao Sihai D, Hu Zhongyi, Greshock Joel, Zhang Youyou, Yang Lu, Zhong Xiaomin, Wang Li-Ping, Jean Stephanie, Li Chunsheng, Huang Qihong, Katsaros Dionyssios, Montone Kathleen T, Tanyi Janos L, Lu Yiling, Boyd Jeff, Nathanson Katherine L, Li Hongzhe, Mills Gordon B, Zhang Lin
Abstract excerpt
In a genome-wide survey on somatic copy-number alterations (SCNAs) of long noncoding RNA (lncRNA) in 2,394 tumor specimens from 12 cancer types, we found that about 21.8% of lncRNA genes were located in regions with focal SCNAs. By integrating bioinformatics analyses of lncRNA SCNAs and expression with functional screening assays, we identified an oncogene, focally amplified lncRNA on chromosome 1 (FAL1), whose...
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