Copy number gain of 1q25 predicts poor progression-free survival for pediatric intracranial ependymomas and enables patient risk stratification: a prospective European clinical trial cohort analysis on behalf of the Children's Cancer Leukaemia Group (CCLG), Societe Francaise d'Oncologie Pediatrique (SFOP), and International Society for Pediatric Oncology (SIOP).

doi:10.1158/1078-0432.CCR-11-2489

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Copy number gain of 1q25 predicts poor progression-free survival for pediatric intracranial ependymomas and enables patient risk stratification: a prospective European clinical trial cohort analysis on behalf of the Children's Cancer Leukaemia Group (CCLG), Societe Francaise d'Oncologie Pediatrique (SFOP), and International Society for Pediatric Oncology (SIOP).

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2012

Kilday John-Paul, Mitra Biswaroop, Domerg Caroline, Ward Jennifer, Andreiuolo Felipe, Osteso-Ibanez Teresa, Mauguen Audrey, Varlet Pascale, Le Deley Marie-Cecile, Lowe James, Ellison David W, Gilbertson Richard J, Coyle Beth, Grill Jacques, Grundy Richard G

Abstract excerpt

PURPOSE: The high incidence of recurrence and unpredictable clinical outcome for pediatric ependymoma reflect the imprecision of current therapeutic staging and need for novel risk stratification markers. We therefore evaluated 1q25 gain across three age- and treatment-defined European clinical trial cohorts of pediatric intracranial ependymoma. EXPERIMENTAL DESIGN: Frequency of 1q gain was assessed across 48...

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PMID: 22338015
DOI: 10.1158/1078-0432.CCR-11-2489

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