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Article

Analysis of <i>HIC‐1</i> methylation and transcription in human ependymomas

15 Mar 2004

Abstract excerpt

Ependymomas are among the most common brain tumors in children. They develop from ependymal cells lining the ventricular system of the CNS. Previous studies have demonstrated a significant rate of allelic loss at chromosome 17p13.3. The HIC-1 putative tumor-suppressor gene, which exhibits hypermethylation and loss of expression in various tumor entities including medulloblastomas and gliomas, maps to the affected...

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PMID: 15122586
DOI: 10.1002/ijc.20165

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