Article
Epigenomic alterations define lethal CIMP-positive ependymomas of infancy.
Nature - 27 Feb 2014
Mack S C, Witt H, Piro R M, Gu L, Zuyderduyn S, Stütz A M, Wang X, Gallo M, Garzia L, Zayne K, Zhang X, Ramaswamy V, Jäger N, Jones D T W, Sill M, Pugh T J, Ryzhova M, Wani K M, Shih D J H, Head R, Remke M, Bailey S D, Zichner T, Faria C C, Barszczyk M, Stark S, Seker-Cin H, Hutter S, Johann P, Bender S, Hovestadt V, Tzaridis T, Dubuc A M, Northcott P A, Peacock J, Bertrand K C, Agnihotri S, Cavalli F M G, Clarke I, Nethery-Brokx K, Creasy C L, Verma S K, Koster J, Wu X, Yao Y, Milde T, Sin-Chan P, Zuccaro J, Lau L, Pereira S, Castelo-Branco P, Hirst M, Marra M A, Roberts S S, Fults D, Massimi L, Cho Y J, Van Meter T, Grajkowska W, Lach B, Kulozik A E, von Deimling A, Witt O, Scherer S W, Fan X, Muraszko K M, Kool M, Pomeroy S L, Gupta N, Phillips J, Huang A, Tabori U, Hawkins C, Malkin D, Kongkham P N, Weiss W A, Jabado N, Rutka J T, Bouffet E, Korbel J O, Lupien M, Aldape K D, Bader G D, Eils R, Lichter P, Dirks P B, Pfister S M, Korshunov A, Taylor M D
Abstract excerpt
Ependymomas are common childhood brain tumours that occur throughout the nervous system, but are most common in the paediatric hindbrain. Current standard therapy comprises surgery and radiation, but not cytotoxic chemotherapy as it does not further increase survival. Whole-genome and whole-exome sequencing of 47 hindbrain ependymomas reveals an extremely low mutation rate, and zero significant recurrent somatic...
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