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Article

FABP4, marker of worse prognosis in cardiovascular disease, induces neutrophil's proatherogenic phenotype which is modulated by semaglutide.

Journal of molecular and cellular cardiology - 1 Jan 2026

Sánchez-López David, García-Vega David, Viñuela J E, Ferreirós-Vidal Isabel, Iglesias-Álvarez Diego, Martínez-Cereijo José Manuel, Reija-López Laura, Fernández-González Ángel L, González-Juanatey José R, Eiras Sonia

Abstract excerpt

Dysfunctional epicardial adiposity is a risk factor for coronary artery disease (CAD). Its genesis is associated with an upregulation of fatty acid binding protein 4 (FABP4) levels, which might exert paracrine inflammatory and atherogenic mechanisms on the cardiovascular system. We aimed to study the prognosis of patients with high systemic FABP4, its association with a neutrophil proatherogenic phenotype,...

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Source

Identifiers

PMID: 41183609
DOI: 10.1016/j.yjmcc.2025.10.009

Genes

FABP4
CAD
CCL5
CXCR2
MMP9
MPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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