Article

No Evidence for Genetic Role of the Tumor Necrosis Factor Pathway in Parkinson’s Disease

2025-09-08

Abstract excerpt

Tumor necrosis factor (TNF) inhibition is under investigation as a therapeutic strategy for Parkinson’s disease (PD) and REM sleep behavior disorder (RBD), yet supporting genetic evidence is limited. We used Summary-data-based Mendelian Randomization (SMR) to test whether expression level of ten TNF-related genes were causally linked to PD risk, PD progression, or RBD risk. We also analyzed associations between co...

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Literature Corpus work: 7ab844f4-eef0-57f8-9820-9837a10bd251
DOI: 10.1101/2025.09.06.25335210

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