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Article

Tumor Necrosis Factor Inhibition and Parkinson Disease: A Mendelian Randomization Study.

Neurology - 23 Mar 2021

Kang Xiaoying, Ploner Alexander, Pedersen Nancy L, Bandres-Ciga Sara, Noyce Alastair J, Wirdefeldt Karin, Williams Dylan M

Abstract excerpt

OBJECTIVE: To evaluate the effects of long-term tumor necrosis factor (TNF) inhibition on the risk and age at onset of Parkinson disease (PD), we performed a 2-sample Mendelian randomization study using genome-wide association studies (GWAS) summary statistics. METHODS: Genetic variants in the vicinity of TNFRSF1A, the gene encoding TNF receptor 1 (TNFR1), were identified as predictive of pharmacologic blockade...

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Source

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Identifiers

PMID: 33608417
DOI: 10.1212/WNL.0000000000011630
PMCID: PMC8032365

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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