Article

Lack of genetic evidence for NLRP3-inflammasome involvement in Parkinson’s disease pathogenesis

2023-09-23

Abstract excerpt

Activation of the NLRP3-inflammasome has been implicated in Parkinson’s disease based on in vitro and in vivo studies. Clinical trials targeting the NLRP3-inflammasome in Parkinson’s disease are ongoing. However, the evidence supporting NLRP3’s involvement in Parkinson’s disease from human genetics data is limited. In this study, we conducted analyses of common and rare variants in NLRP3-inflammasome related genes...

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Literature Corpus work: e91b96ea-d23e-5292-a632-473840ce2b7d
DOI: 10.1101/2023.09.20.23295790

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