Article
Elusive inheritance: Transgenerational effects and epigenetic inheritance in human environmental disease.
Progress in biophysics and molecular biology - 1 Jul 2015
Martos Suzanne N, Tang Wan-Yee, Wang Zhibin
Abstract excerpt
Epigenetic mechanisms involving DNA methylation, histone modification, histone variants and nucleosome positioning, and noncoding RNAs regulate cell-, tissue-, and developmental stage-specific gene expression by influencing chromatin structure and modulating interactions between proteins and DNA. Epigenetic marks are mitotically inherited in somatic cells and may be altered in response to internal and external...
Topics
- Animals
- Disease
- Environment
- Epigenesis, Genetic
- Humans
- Inheritance Patterns
- Phenotype
