Mechanisms of transgenerational epigenetic inheritance: lessons from animal model organisms.

Abstract excerpt

Epigenetic inheritance is a phenomenon whereby stochastic or signal-induced changes to parental germline epigenome modulate phenotypic output in one or more subsequent generations, independently of mutations in the genomic DNA. While the number of reported epigenetic inheritance phenomena across phyla is exponentially growing, much remains to be elucidated about their mechanistic underpinnings, and their...

Topics

• Animals
• Humans
• Epigenesis, Genetic
• Epigenomics
• Phenotype
• Models, Animal
• Adaptation, Physiological
• Inheritance Patterns
• DNA Methylation