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Article

Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker.

Nature communications - 17 Jun 2021

Blake Georgina E T, Zhao Xiaohui, Yung Hong Wa, Burton Graham J, Ferguson-Smith Anne C, Hamilton Russell S, Watson Erica D

Abstract excerpt

The mechanism behind transgenerational epigenetic inheritance is unclear, particularly through the maternal grandparental line. We previously showed that disruption of folate metabolism in mice by the Mtrr hypomorphic mutation results in transgenerational epigenetic inheritance of congenital malformations. Either maternal grandparent can initiate this phenomenon, which persists for at least four wildtype...

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Identifiers

PMID: 34140513
DOI: 10.1038/s41467-021-24036-5
PMCID: PMC8211854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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