Article
Association between Taxonomic Composition of Gut Microbiota and Host Single Nucleotide Polymorphisms in Crohn's Disease Patients from Russia.
International journal of molecular sciences - 28 Apr 2023
Markelova Maria, Senina Anastasia, Khusnutdinova Dilyara, Siniagina Maria, Kupriyanova Elena, Shakirova Gulnaz, Odintsova Alfiya, Abdulkhakov Rustam, Kolesnikova Irina, Shagaleeva Olga, Lyamina Svetlana, Abdulkhakov Sayar, Zakharzhevskaya Natalia, Grigoryeva Tatiana
Abstract excerpt
Crohn's disease (CD) is a chronic relapsing inflammatory bowel disease of unknown etiology. Genetic predisposition and dysbiotic gut microbiota are important factors in the pathogenesis of CD. In this study, we analyzed the taxonomic composition of the gut microbiota and genotypes of 24 single nucleotide polymorphisms (SNP) associated with the risk of CD. The studied cohorts included 96 CD patients and 24 healthy...
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