Article

Gut microbial structural variation improves disease discrimination and reveals a strain-level regulatory mechanism in rheumatoid arthritis

2026-07-27

Abstract excerpt

Gut microbial structural variation captures strain-level genomic diversity beyond species abundance, yet its contribution to rheumatoid arthritis (RA) remains unclear. Integrating gut metagenomic datasets from four independent cohorts (n = 491), we identified reproducible RA-associated structural variants (SVs), most of which occurred in species without differential abundance. Incorporating SVs into machine learni...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7e8f87ef-3660-56f1-aae0-7751c1cbcdfd
DOI: 10.64898/2026.07.23.26358822

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gut microbial structural variation improves disease discrimination and reveals a strain-level regulatory mechanism in rheumatoid arthritisDOI 10.64898/2026.07.23.26358822Read

The rheumatoid arthritis gut microbial biobank reveals core microbial species that associate and effect on host inflammation and autoimmune responsesSemantic proximity Read

Bacterial clade-specific analysis identifies distinct epithelial responses in inflammatory bowel diseaseSemantic proximity Read

Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arthritis phenotypes.Semantic proximity Read

Discovery of disease-adapted bacterial lineages in inflammatory bowel diseases.Semantic proximity Read

Genomic and ecologic characteristics of the airway microbial-mucosal complexSemantic proximity Read

Microbial dysbiosis and metabolic disorders promote rheumatoid arthritis across successive stages: a multi-omics cohort studySemantic proximity Read

Quantifying Metagenomic Strain Associations from Microbiomes with AnpanSemantic proximity Read

Meta-analysis defines predominant shared microbial responses in various diseases and a specific inflammatory bowel disease signalSemantic proximity Read

Gene-level metagenomic architectures across diseases yield high-resolution microbiome diagnostic indicatorsSemantic proximity Read

Multikingdom characterization of gut microbiota in patients with rheumatoid arthritis and rheumatoid arthritis‐associated interstitial lung diseaseSemantic proximity Read

Causal relationship between gut microbiota and rheumatoid arthritis: a two-sample Mendelian randomisation study.Semantic proximity Read

Improved detection of microbiome-disease associations via population structure-aware generalized linear mixed effects models (microSLAM)Semantic proximity Read