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Article

Uncovering the Single Amino-Acid Polymorphisms of the Human Gut Ecosystem.

Journal of proteome research - 4 Jul 2025

Xue Kewen, Wang Panpan, Lin Qixiao, Xie Junhua, Cong Li, Yan Zhixiang

Abstract excerpt

Single nucleotide polymorphisms (SNPs) are the most common type of genetic variation in the gut microbial metagenome and the host genome, but they could not adequately represent the protein-level variants. Single amino-acid polymorphisms (SAP) derived from nonsynonymous SNPs can cause functional changes of proteins and are important forces of adaption. However, SAP remains quite unexplored for the human gut...

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PMID: 40499078
DOI: 10.1021/acs.jproteome.5c00108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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