Article

Nested small open reading frames are translated from alternative transcripts

2024-10-25

Abstract excerpt

Overlapping genes were thought to be essentially absent from the human genome until the discovery of hundreds of translated, frameshifted internal open reading frames (iORFs) within annotated protein coding sequences (CDS). This would suggest that some human genes encode two completely different proteins; however, it is unclear how iORF-encoded proteins are translated, and whether they are broadly functional. We d...

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Literature Corpus work: 7a801a60-b30a-55d4-9b10-883df2d83303
DOI: 10.1101/2024.10.22.619581

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