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Single‐cell transcriptome analyses reveal heterogeneity in suspension cultures and clonal markers of CHO‐K1 cells

12 Nov 2020

Abstract excerpt

Cell-to-cell variability in cell populations arises from a combination of intrinsic factors and extrinsic factors related to the milieu. However, the heterogeneity of high cell density suspension cultures for therapeutic protein production remains unknown. Here, we illustrate the increasing heterogeneity in the cellular transcriptome of serum-free adapted CHO K1 cells during high cell density suspension culture...

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PMID: 33179258
DOI: 10.1002/bit.27624

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