Article

Loss of GRLF1 induces aneuploidy and enhances bladder cancer cell migration and invasion by modulating actin dynamics

2025-05-07

Abstract excerpt

<title>Abstract</title> <p> A previous RNA interference (RNAi) screening approach in our laboratory identified GRLF1, a GTPase-activating protein that regulates the Rho family of small GTPases, as a ploidy-control gene, which implied a potential function of GRLF1 in genome stability. GRLF1 has been studied across various cancer types, but previous studies revealed contradictory results as to whether GRLF1 is a t...

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Literature Corpus work: f4a3a599-4078-5005-a33f-82b4f97706c3
DOI: 10.21203/rs.3.rs-6362761/v1

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