Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional signatures of Ral GTPase are associated with aggressive clinicopathologic characteristics in human cancer.

Cancer research - 15 Jul 2012

Smith Steven C, Baras Alexander S, Owens Charles R, Dancik Garrett, Theodorescu Dan

Abstract excerpt

RalA and RalB are small GTPases that support malignant development and progression in experimental models of bladder, prostate, and squamous cancer. However, demonstration of their clinical relevance in human tumors remains lacking. Here, we developed tools to evaluate Ral protein expression, activation, and transcriptional output and evaluated their association with clinicopathologic parameters in common human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Squamous Cell
Share to Enzyme Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunohistochemistry

Share to Neoplasm Invasiveness

Share to Neoplasm Metastasis

Share to Neoplastic Stem Cells

Share to RNA, Small Interfering

Share to Urinary Bladder Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 22586063
DOI: 10.1158/0008-5472.CAN-11-3966
PMCID: PMC3842017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional signatures of Ral GTPase are associated with aggressive clinicopathologic characteristics in human cancer.PMID 22586063Read ↗

Expression of ral GTPases, their effectors, and activators in human bladder cancer.Semantic proximity Read ↗

Effects of RAL signal transduction in KRAS- and BRAF-mutated cells and prognostic potential of the RAL signature in colorectal cancer.Semantic proximity Read ↗

Autocrine Signaling by Receptor Tyrosine Kinases in Urothelial Carcinoma of the BladderSemantic proximity Read ↗

Epigenomic mapping identifies a super-enhancer repertoire that regulates cell identity in bladder cancers through distinct transcription factor networksSemantic proximity Read ↗

Epigenomic mapping identifies an enhancer repertoire that regulates cell identity in bladder cancer through distinct transcription factor networksSemantic proximity Read ↗

Ral signaling pathway in health and cancer.Semantic proximity Read ↗

The Ral GTPase pathway in metastatic bladder cancer: key mediator and therapeutic target.Semantic proximity Read ↗

FOXA1, GATA3 and PPARɣ Cooperate to Drive Luminal Subtype in Bladder Cancer: A Molecular Analysis of Established Human Cell LinesSemantic proximity Read ↗

Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma.Semantic proximity Read ↗

Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulationSemantic proximity Read ↗

Androgen Receptor Regulates CD44 Expression in Bladder CancerSemantic proximity Read ↗

Loss of GRLF1 induces aneuploidy and enhances bladder cancer cell migration and invasion by modulating actin dynamicsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.