Article

A partitioned polygenic risk score reveals distinct contributions to psoriasis clinical phenotypes across a multi-racial cohort

2024-04-19

Abstract excerpt

<title>Abstract</title> <p>Psoriasis is a chronic, immune-mediated inflammatory skin disease associated with a polygenic mode of inheritance. There are few studies that explore the association of a psoriasis Polygenic Risk Score (PRS) with patient clinical characteristics, and to our knowledge there are no studies examining psoriasis PRS associations across different races. In this study, we used a multi-racial p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7a337321-2304-54a5-b79c-a65e286ba788
DOI: 10.21203/rs.3.rs-4224896/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A partitioned polygenic risk score reveals distinct contributions to psoriasis clinical phenotypes across a multi-racial cohortDOI 10.21203/rs.3.rs-4224896/v1Read

A partitioned polygenic risk score reveals distinct contributions to psoriasis clinical phenotypes across a multi-ethnic cohort.Semantic proximity Read

Genetic liability to psoriasis predicts severe disease outcomesSemantic proximity Read

Genome‑wide association study and polygenic risk scores predict psoriasis and its shared phenotypes in Taiwan.Semantic proximity Read

Genetic liability to psoriasis predicts severe disease outcomes.Semantic proximity Read

A genetic risk score combining ten psoriasis risk loci improves disease prediction.Semantic proximity Read

Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasisSemantic proximity Read

Associations of plasma proteomic and polygenic profiling with incident psoriasis risk: a prospective cohort study.Semantic proximity Read

Common variants explain a large fraction of the variability in the liability to psoriasis in a Han Chinese population.Semantic proximity Read

A novel polygenic risk score model based on the protein interactions: An application on psoriasisSemantic proximity Read

Psoriasis and Genetics.Semantic proximity Read

Genetic Studies Investigating Susceptibility to Psoriatic Arthritis: A Narrative Review.Semantic proximity Read

Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for PsoriasisSemantic proximity Read