Article
Common variants explain a large fraction of the variability in the liability to psoriasis in a Han Chinese population.
BMC genomics - 30 Jan 2014
Yin Xianyong, Wineinger Nathan E, Cheng Hui, Cui Yong, Zhou Fusheng, Zuo Xianbo, Zheng Xiaodong, Yang Sen, Schork Nicholas J, Zhang Xuejun
Abstract excerpt
BACKGROUND: Psoriasis is a common inflammatory skin disease with a known genetic component. Our previously published psoriasis genome-wide association study identified dozens of novel susceptibility loci in Han Chinese. However, these markers explained only a small fraction of the estimated heritable component of psoriasis. To better understand the unknown yet likely polygenic architecture in psoriasis, we...
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