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Article

A partitioned polygenic risk score reveals distinct contributions to psoriasis clinical phenotypes across a multi-ethnic cohort.

Journal of translational medicine - 11 Sept 2024

Orcales Faye, Kumar Sugandh, Bui Audrey, Johnson Chandler, Liu Jared, Huang Zhi-Ming, Liao Wilson

Abstract excerpt

Psoriasis is a chronic, immune-mediated inflammatory skin disease associated with a polygenic mode of inheritance. There are few studies that explore the association of a psoriasis Polygenic Risk Score (PRS) with patient clinical characteristics, and to our knowledge there are no studies examining psoriasis PRS associations across different ethnicities. In this study, we used a multi-racial psoriasis cohort to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39261909
DOI: 10.1186/s12967-024-05591-z
PMCID: PMC11389070

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