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Article

Zinc binding loop mutations of hSOD1 promote amyloid fibrils under physiological conditions: Implications for initiation of amyotrophic lateral sclerosis.

Biochimie - 1 Aug 2022

Baziyar Payam, Seyedalipour Bagher, Hosseinkhani Saman

Abstract excerpt

Neurotoxic species of misfolded hSOD1 are involved in the process of causing amyotrophic lateral sclerosis (ALS), which is a devastating neurodegenerative disease. Considerable evidence exists on that hSOD1 mutants-mediated toxicity is resulted from gain-of-function, while the mechanism of this toxicity is unknown yet. In the present study, we focused on the possible mechanism of two point-mutations (namely L67P...

Topics

Amyloid
Amyotrophic Lateral Sclerosis
Humans
Mutation
Neurodegenerative Diseases
Superoxide Dismutase
Superoxide Dismutase-1
Zinc

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35537620
DOI: 10.1016/j.biochi.2022.05.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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