Article
A Histidine Switch for Zn-Induced Aggregation of γ-Crystallins Reveals a Metal-Bridging Mechanism That Is Relevant to Cataract Disease.
Biochemistry - 21 Aug 2018
Domínguez-Calva José Antonio, Haase-Pettingell Cameron, Serebryany Eugene, King Jonathan Alan, Quintanar Liliana
Abstract excerpt
Cataract disease results from non-amyloid aggregation of eye lens proteins and is the leading cause of blindness in the world. Zinc concentrations in cataractous lenses are increased significantly relative to those in healthy lenses. It was recently reported that Zn(II) ions induce the aggregation of one of the more abundant proteins in the core of the lens, human γD-crystallin. Here, the mechanism of Zn-induced...
Topics
- Cataract
- Edetic Acid
- Histidine
- Humans
- Mutation
- Protein Binding
- Protein Multimerization
- Zinc
- gamma-Crystallins