Article

Positive germline selection of mtDNA: evidence from the oocyte

2026-01-09

Abstract excerpt

Purifying selection is the removal of detrimental mutations. Nuclear DNA mutations are purged by removing mutant individuals, embryos, or germline cells. Because mtDNA is present in numerous copies per cell, purifying selection of mtDNA mutations introduces an additional layer of complexity. The intracellular mutant fraction can change due to clonal expansion/reduction of mutant mtDNA molecules in germline cells....

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Literature Corpus work: 3f84fbc9-356b-5d9d-bdc2-2df7248afa28
DOI: 10.64898/2025.12.31.697248

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