Article
Essential embryonic roles of the CKI-1 cyclin-dependent kinase inhibitor in cell-cycle exit and morphogenesis in C elegans.
Developmental biology - 1 Aug 2003
Fukuyama Masamitsu, Gendreau Steven B, Derry W Brent, Rothman Joel H
Abstract excerpt
Following a phase of rapid proliferation, cells in developing embryos must decide when to cease division and then whether to survive and differentiate or instead undergo programmed death. In screens for genes that regulate embryonic patterning of the endoderm in Caenorhabditis elegans, we identified overlapping chromosomal deletions that define a gene required for these decisions. These deletions result in...
Topics
- Animals
- Apoptosis
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Cycle
- Cell Cycle Proteins
- Cell Differentiation
- Cell Division
- Cell Lineage
- Chromosome Deletion
- Cyclin-Dependent Kinase Inhibitor Proteins
- Cyclin-Dependent Kinases
- Embryo, Nonmammalian