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Mitochondrial Phenotypes in Genetically Diverse Neurodegenerative Diseases and Their Response to Mitofusin Activation.

Cells - 21 Mar 2022

Dang Xiawei, Walton Emily K, Zablocka Barbara, Baloh Robert H, Shy Michael E, Dorn Gerald W

Abstract excerpt

Mitochondrial fusion is essential to mitochondrial fitness and cellular health. Neurons of patients with genetic neurodegenerative diseases often exhibit mitochondrial fragmentation, reflecting an imbalance in mitochondrial fusion and fission (mitochondrial dysdynamism). Charcot-Marie-Tooth (CMT) disease type 2A is the prototypical disorder of impaired mitochondrial fusion caused by mutations in the fusion...

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PMID: 35326504
DOI: 10.3390/cells11061053
PMCID: PMC8947610

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