Article
CMT2A-linked MFN2 mutation, T206I promotes mitochondrial hyperfusion and predisposes cells towards mitophagy.
Mitochondrion - 1 Jan 2024
Das Rajdeep, Maity Sebabrata, Das Palamou, Kamal Izaz Monir, Chakrabarti Saikat, Chakrabarti Oishee
Abstract excerpt
Mutations in Mitofusin2 (MFN2) associated with the pathology of the debilitating neuropathy Charcot-Marie-Tooth type 2A (CMT2A) are known to alter mitochondrial morphology. Previously, such mutations have been shown to elicit two diametrically opposite phenotypes - while some mutations have been causally linked to enhanced mitochondrial fragmentation, others have been shown to induce hyperfusion. Our study...
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