Article

HIV-1 Tat protein exposure alters the morphological characteristics and gene expression in the primary mouse cortex endothelial cells and human brain microvascular endothelial cells

2025-10-20

Abstract excerpt

<title>Abstract</title> <p> HIV-1-associated neurocognitive disorders (HAND) are highly prevalent in the era of combination of antiretroviral therapies. Recent studies suggest that damage of blood-brain barrier (BBB) may serve as an early biomarker of cognitive dysfunction in people living with HIV. This is due to the ability of HIV-1, along with infected monocytes and macrophages, to traverse the BBB via either...

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Literature Corpus work: 586b2d8a-a354-54fb-92f0-204982bd3ac6
DOI: 10.21203/rs.3.rs-7736511/v1

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