Article

The Genetic Fingerprint of HIV in the Brain: Insights into Neurocognitive Dysfunction

2025-04-15

Abstract excerpt

HIV, primarily targeting CD4 cells, infiltrates the CNS through various mechanisms, including chemokine-mediated signaling and disruption of the blood-brain barrier, leading to neuroinflammation and neuronal dysfunction. Viral proteins such as gp120, Tat, and Vpr directly induce neurotoxicity, oxidative stress, and mitochondrial dysfunction, exacerbating cognitive deficits and motor impairments observed in HIV-ass...

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Literature Corpus work: c267654f-9278-51a8-8283-83c137f8da96
DOI: 10.20944/preprints202504.1024.v1

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