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Article

Neanderthal introgression reintroduced functional ancestral alleles lost in Eurasian populations.

Nature ecology & evolution - 1 Oct 2020

Rinker David C, Simonti Corinne N, McArthur Evonne, Shaw Douglas, Hodges Emily, Capra John A

Abstract excerpt

Neanderthal ancestry remains across modern Eurasian genomes and introgressed sequences influence diverse phenotypes. Here, we demonstrate that introgressed sequences reintroduced thousands of ancestral alleles that were lost in Eurasian populations before introgression. Our simulations and variant effect predictions argue that these reintroduced alleles (RAs) are more likely to be tolerated by modern humans than...

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PMID: 32719451
DOI: 10.1038/s41559-020-1261-z
PMCID: PMC7529911

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