Article

The borders of <i>cis</i> -regulatory DNA sequences harbor the divergent transcription factor binding motifs in the human genome

2018-08-02

Abstract excerpt

Changes in the cis -regulatory DNA sequences and transcription factor (TF) repertoires provide major sources that shape the gene regulatory evolution in eukaryotes. However, it is currently unclear how dynamic change of DNA sequences introduce various divergence level of TF binding motifs in the genome over evolutionary time. Here, we estimated the evolutionary divergence level of the TF binding motifs, and quant...

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Literature Corpus work: 447a1f06-1902-5573-a513-e08f40a431ca
DOI: 10.1101/383182

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