Article

LiBis: An ultrasensitive alignment method for low-input bisulfite sequencing

2020-05-16

Abstract excerpt

The cell-free DNA (cfDNA) methylation profile in liquid biopsies has been utilized to diagnose early-stage disease and estimate therapy response. However, in typical clinical settings, only very small amounts of cfDNA can be purified. Whole-genome bisulfite sequencing (WGBS) is the gold standard to measure DNA methylation; however, WGBS using small amounts of fragmented DNA introduces a critical challenge for data...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 79d4adb1-2523-5b21-ae2e-24eecdeb58f1
DOI: 10.1101/2020.05.14.096461

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

LiBis: An ultrasensitive alignment method for low-input bisulfite sequencingDOI 10.1101/2020.05.14.096461Read

cfDNApipe: a comprehensive quality control and analysis pipeline for cell-free DNA high-throughput sequencing dataSemantic proximity Read

The BisPCR2 method for targeted bisulfite sequencingSemantic proximity Read

Hypomethylation in HBV integration regions aids non-invasive surveillance to hepatocellular carcinoma by low-pass genome-wide bisulfite sequencingSemantic proximity Read

A pooling-based approach to mapping genetic variants associated with DNA methylation.Semantic proximity Read

Systematic and benchmarking studies of pipelines for mammal WGBS data in the novel NGS platformSemantic proximity Read

Ultradeep bisulfite sequencing analysis of DNA methylation patterns in multiple gene promoters by 454 sequencing.Semantic proximity Read

A new approach to decode DNA methylome and genomic variants simultaneously from double strand bisulfite sequencing.Semantic proximity Read

Heatrich-BS enables efficient CpG enrichment and highly scalable cell-free DNA methylation profilingSemantic proximity Read

Correcting Methylation Calls in Clinically Relevant Low-Mappability RegionsSemantic proximity Read

Pash 3.0: A versatile software package for read mapping and integrative analysis of genomic and epigenomic variation using massively parallel DNA sequencing.Semantic proximity Read

Analyzing the cancer methylome through targeted bisulfite sequencing.Semantic proximity Read

GBS-MeDIP: A protocol for parallel identification of genetic and epigenetic variation in the same reduced fraction of genomes across individuals.Semantic proximity Read